Editorial: “Transcellular Cycles Underlying Neurotransmission”

Neuronal action potentials and neurotransmitter releases induce important alterations in the extracellular millieu, including increased K concentrations from membrane repolarization and increased neurotransmitter levels from trans-synaptic signaling (1, 2). It becomes crucial then to remove, fast and efficiently, these ionic and neurotransmitter surges and to prepare the synapsis for a new neurotransmission event (3). In parallel, the energy demands of these metabolic movements must be fulfilled from substrates, such as glucose and lactate, obtained from cerebrovascular supplies (4, 5). Surrounding astrocytes coordinate all these tasks, playing a central role during neurotransmission, many times operating intercellularly as astrocytic networks (6, 7). Summarizing, the adequate operation of neurotransmission requires the transcellular coupling of neuronal and astrocytic metabolisms to a suitable supply of metabolic substrates from the microvasculature. Pathological alterations in these processes underlie the most morbid and prevalent neurological disorders, including ischemic or traumatic episodes and neurodegeneration. Despite enormous progress in our understanding of neurotransmission during the last decades, important questions remain insufficiently explored including the quantitative assessment of transcellular cycles of glutamate, glutamine, and GABA supporting glutamatergic or gabaergic neurotransmissions, the preferred metabolic substrates, as glucose and/or lactate, supporting the energy demands under resting or stimulated conditions, and the mechanisms underlying neurovascular coupling. In addition, the important question on how all these processes occur and integrate under the in vivo situation reaches, in this context, vital relevance. Recently, a variety of non-invasive approaches have allowed the investigation of these aspects in vivo (8), outstandingly, those involving functional magnetic resonance imaging and 13Cmagnetic resonance spectroscopy methods. The following e-book entitled “Transcellular Cycles Underlying Neurotransmission” provides an authoritative overview of these issues, compiling contributions from leading scientists in this field. In the study of neuroglial interactions in vivo, Rodrigues et al. (9) provide a convenient introduction to the fundamentals of 13C NMR spectroscopy and its applications to cerebral energy metabolism, Duarte et al. (10) report on the compartmentalized metabolism of (1,6-C2) glucose in the brain in vivo, Shen (11) reviews the mathematical modeling strategies used to simulate quantitatively the operation glutamate–glutamine cycle in vivo, and Sampol et al. (12) address the metabolism of glucose and lactate in the stimulated, awake, rat brain. Similarly, Bartnick-Olson et al. (13) illustrate the use of 13CNMR to evaluate the altered neuroglial interactions in response to traumatic brain injury. The neurophysiological, metabolic, and cellular compartmentation events underlying functional neuroimaging by MRI are discussed by Moreno et al. (14), while Lizarbe et al. (15) cover the use of different MRI andMRS strategies to evaluate the ionic responses during hypothalamic activation by appetite stimulation. The role of astrocytic metabolic networks in metabolic coupling is discussed